Down-regulation of P4501A1 and P4501A2 mRNA expression in isolated hepatocytes by oxidative stress.
نویسندگان
چکیده
منابع مشابه
Chloroacetonitrile-Induced Cytotoxicity and Oxidative Stress in Isolated Rat Hepatocytes
Chloroacetonitrile (CAN) is a disinfectant by-product of drinking water chlorination. The present work was designed to investigate the cytotoxic effects as well as the oxidative stress induced by CAN in isolated rat hepatocytes. Hepatocytes were exposed to different concentrations of CAN (5–40 μM) in a time-course experiment for up to 2 h. CAN exposure induced a significant decrease in cell via...
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In vitro nuclear run-on transcription analysis using probes directed against different regions of CYP1A2 revealed that the 70-100-fold induction of CYP1A2 mRNA by polycyclic aromatic compounds is associated with a corresponding increase in the transcriptional activation of this gene in rat liver. Probes from regions of the 1st, 2nd, and 4th introns detected approximately 50-100-fold higher CYP1...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1994
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)41731-5